Description: Midodrine-d6 is intended for use as an internal standard for the quantification of midodrine by GC- or LC-MS. Midodrine is a prodrug form of the α1-adrenergic receptor (α1-AR) agonist desglymidodrine. It is converted to desglymidodrine by enzymatic hydrolysis. Midodrine (5 mg/kg) increases mean arterial pressure (MAP) and decreases heart rate in normotensive rats.2 Formulations containing midodrine have been used in the treatment of orthostatic hypotension.

Name: Midodrine-d6 HCl
CAS#: 1188265-43-1
Chemical Formula: C12H13D6ClN2O4
Exact Mass: 296.141
Molecular Weight: 296.7806
Elemental Analysis: C, 48.57; H, 8.49; Cl, 11.94; N, 9.44; O, 21.56

Synonym: Midodrine-d6 HCl; Midodrine d6 HCl; Midodrine-d6 hydrochloride; Midodrine d6 hydrochloride;

IUPAC/Chemical Name: 2-amino-N-(2-(2,5-bis(methoxy-d3)phenyl)-2-hydroxyethyl)acetamide hydrochloride

InChi Key: MGCQZNBCJBRZDT-TXHXQZCNSA-N

InChi Code: InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H/i1D3,2D3;

SMILES Code: NCC(NCC(O)C1=C(OC([2H])([2H])[2H])C=CC(OC([2H])([2H])[2H])=C1)=O.Cl

Appearance: Solid powder

Purity: >99% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001