Description: Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264.7 cells in vitro when used at concentrations ranging from 1 to 100 μM. Metaxalone also reduces LPS-induced increases in COX-1, COX-2, and NF-kB levels and inhibits LPS-induced production of TNF-α, IL-6, and prostaglandin E2 in RAW 264.7 cells. Formulations containing metaxalone have been used in the treatment of lower back pain.

Name: Metaxalone-d6
CAS#: 1189944-95-3
Chemical Formula: C12H9D6NO3
Exact Mass: 227.1429
Molecular Weight: 227.2926
Elemental Analysis: C, 63.41; H, 9.31; N, 6.16; O, 21.12

Synonym: Metaxalone-d6; Metaxalone d6;

IUPAC/Chemical Name: 5-((3,5-bis(methyl-d3)phenoxy)methyl)oxazolidin-2-one

InChi Key: IMWZZHHPURKASS-WFGJKAKNSA-N

InChi Code: InChI=1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14)/i1D3,2D3

SMILES Code: [2H]C([2H])(C1=CC(C([2H])([2H])[2H])=CC(OCC(CN2)OC2=O)=C1)[2H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001