Description: Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells, which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells, which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 65 and 54 μM, respectively. It reduces carrageenan-induced paw edema in rats when administered intravenously at doses ranging from 0.1 to 9 mg/kg. Formulations containing lornoxicam have been used in the management of postoperative pain.

Name: Lornoxicam-d4
CAS#: 1216527-48-8
Chemical Formula: C13H6D4ClN3O4S2
Exact Mass: 375.0052
Molecular Weight: 375.8344
Elemental Analysis: C, 41.55; H, 3.75; Cl, 9.43; N, 11.18; O, 17.03; S, 17.06

Synonym: Lornoxicam-d4; Lornoxicam d4; Chlortenoxicam-d4; Chlortenoxicam d4; Ro 13-9297-d4; Ro 13-9297 d4;

IUPAC/Chemical Name: 6-chloro-4-hydroxy-2-methyl-N-(pyridin-2-yl-d4)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide

InChi Key: WLHQHAUOOXYABV-QFFDRWTDSA-N

InChi Code: InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)/i2D,3D,4D,5D

SMILES Code: OC(C1=C2C=C(Cl)S1)=C(N(S2(=O)=O)C)C(NC3=C(C([2H])=C(C([2H])=N3)[2H])[2H])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001