Description: Harringtonine is found in Cephalotaxuts. It immobilizes initiated ribtosomes, inhibiting protein translation by blocking the ribosomal A site. It suppresses viral replication and protein expression in chikungunya virus infection, inhibits cell growth in actue promyelocytic leukemia cells, and induces apoptosis in leukemia cells.

Synonym: 2'R-Harringtonine; Harringtonine; Alkaloid C from cephalotaxus; NSC 124147; NSC-124147; NSC124147.

IUPAC/Chemical Name: 1-((1S,3aR,14bS)-2-methoxy-1,5,6,8,9,14b-hexahydro-4H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]cyclopenta[b]pyrrolo[1,2-a]azepin-1-yl) 4-methyl (R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)succinate

InChi Key: HAVJATCHLFRDHY-KSZYUSJVSA-N

InChi Code: InChI=1S/C28H37NO9/c1-26(2,32)8-9-28(33,15-22(30)35-4)25(31)38-24-21(34-3)14-27-7-5-10-29(27)11-6-17-12-19-20(37-16-36-19)13-18(17)23(24)27/h12-14,23-24,32-33H,5-11,15-16H2,1-4H3/t23-,24-,27+,28-/m1/s1

SMILES Code: O=C(O[C@@H]1C(OC)=C[C@]2(CCC3)N3CCC4=CC5=C(OCO5)C=C4[C@@]21[H])[C@](CCC(C)(O)C)(O)CC(OC)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001