Description: FB23 is a potent and selective inhibitor of N6-methyladenosine (m6A) demethylase FTO (fat mass and obesity associated protein). It moderately inhibits proliferation of NB4 and MONOMAC6 cells. FB23 demonstrates its potent inhibitory impact in AML models.

Name: FB23 inhibitor
CAS#: 2243736-35-6
Chemical Formula: C18H14Cl2N2O3
Exact Mass: 376.0381
Molecular Weight: 377.221
Elemental Analysis: C, 57.31; H, 3.74; Cl, 18.80; N, 7.43; O, 12.72

Synonym: FB23 inhibitor; FB-23; FB 23;

IUPAC/Chemical Name: 2-[[2,6-Dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]benzoic acid

InChi Key: VUXZATVQMFSUCM-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H14Cl2N2O3/c1-9-16(10(2)25-22-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(23)24/h3-8,21H,1-2H3,(H,23,24)

SMILES Code: O=C(O)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)ON=C3C)C=C2Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001