AGN-194310-北京百奥创新科技有限公司

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AGN-194310

品牌：MedKoo

产地：美国

货号：407164

cas：229961-45-9

发布日期： 2022-07-20
更新日期： 2024-08-12

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产地	美国
品牌	MedKoo
货号	407164
用途	This product is for research use only, not for human or veterinary use.
包装规格	10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg;
CAS编号	229961-45-9
纯度	>98%%
是否进口	是

Description: AGN-194310, also known as VTP-194310, is a pan-antagonist of retinoic acid receptors (RARs) with Kd values of 3nM, 2nM and 5nM for RAR α, RARβ and RARγ, respectively. AGN 194310 has been reported to bind to RARs with equal and high Kd values of 3, 2 and 5nM for RAR α, RARβ and RARγ, respectively, by in vitro binding experiments. In addition, AGN 194310 has been revealed to potently inhibit the colony formation by ITS+-grown cell lines with IC50 values of 16 ± 5nM for LNCaP cells; 18 ± 6nM for PC3 cells; and 34 ± 7nM for DU-145 cells. Apart from these, because of binding to and mediating the effects via RARs, AGN 194310 has been demonstrated to inhibit agonist-induced (TTNPB) differentiation of HL60 cells. AGN 194310 has also shown the accumulation of cell in G1 and the function of induced apoptosis.

Synonym: AGN 194310; AGN194310; AGN-194310; VTP-194310; VTP 194310; VTP194310;

IUPAC/Chemical Name: 4-((4-(4-ethylphenyl)-2,2-dimethyl-2H-thiochromen-6-yl)ethynyl)benzoic acid

InChi Key: LHUPKWKWYWOMSK-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H24O2S/c1-4-19-7-12-22(13-8-19)25-18-28(2,3)31-26-16-11-21(17-24(25)26)6-5-20-9-14-23(15-10-20)27(29)30/h7-18H,4H2,1-3H3,(H,29,30)

SMILES Code: O=C(O)C1=CC=C(C#CC2=CC(C(C3=CC=C(CC)C=C3)=CC(C)(C)S4)=C4C=C2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001